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KMID : 0043320110340101633
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Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1633 ~ p.1637
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A β-resorcylic macrolide from the seagrass-derived fungus Fusarium sp. PSU-ES73
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Arunpanichlert Jiraporn
Rukachaisirikul Vatcharin
Sukpondma Yaowapa
Phongpaichit Souwalak
Supaphon Orathai
Sakayaroj Jariya
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Abstract
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A new β-resorcylic macrolide, 5′-hydroxyzearalenone (1), and six known β-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.
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KEYWORD
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β-Resorcylic macrolide, Fusarium sp., Antibacterial activity, Staphylococcus aureus, Antifungal activity, Cryptococcus neoformans
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